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-The Crabtree effect can be observed when the 02 consumption of tumour cells or of mammalian cells grown in culture is measured in physiological medium containing glucose. The effect of 2 hypoxic cell radiosensitizers, misonidazole and NDPP, on the O2 consumption of Ehrlich ascites tumour cells was compared in media with and without glucose. A stimulatory effect on 02 consumption was found for 5-20mM misonidazole as well as for 0 5mM NDPP, both in media containing 10-2M glucose. Thus glucose induced a Crabtree effect in Ehrlich tumour cells, expressed as 38-45 o inhibition of 02 consumption relative to that in the same medium without glucose. The stimulatory effect of misonidazole and NDPP on 02 utilization in medium with glucose undoubtedly appeared as a release from the Crabtree effect.